diff --git a/CHANGELOG.md b/CHANGELOG.md
index 536da3b..9a165c4 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -9,6 +9,8 @@
 <!-- - Create Github release with updated links from `doc/links.md` -->
 <!-- - `bb gh-pages` -->
 
+- [#102](https://github.com/babashka/scittle/issues/102): add `applied-science/js-interop` plugin.
+
 ## v0.6.22 (2024-12-19)
 
 - [#99](https://github.com/babashka/babashka/issues/99): make `js/import` work
diff --git a/deps.edn b/deps.edn
index b21df7f..c21aef5 100644
--- a/deps.edn
+++ b/deps.edn
@@ -11,6 +11,7 @@
   cljsjs/react-dom {:mvn/version "18.2.0-1"}
   cljsjs/react-dom-server {:mvn/version "18.2.0-1"}
   cljs-ajax/cljs-ajax {:mvn/version "0.8.4"}
+  applied-science/js-interop {:mvn/version "0.4.2"}
   funcool/promesa {:mvn/version "11.0.678"}
   io.github.babashka/sci.nrepl
   #_{:local/root "../sci.nrepl"}
diff --git a/shadow-cljs.edn b/shadow-cljs.edn
index 47e5deb..73529a6 100644
--- a/shadow-cljs.edn
+++ b/shadow-cljs.edn
@@ -18,6 +18,8 @@
                     :depends-on #{:scittle}}
     :scittle.promesa {:entries [scittle.promesa]
                       :depends-on #{:scittle}}
+    :scittle.js-interop {:entries [scittle.js-interop]
+                        :depends-on #{:scittle}}
     :scittle.pprint {:entries [scittle.pprint]
                      :depends-on #{:scittle}}
     :scittle.reagent {:entries [scittle.reagent]
diff --git a/src/scittle/js_interop.cljs b/src/scittle/js_interop.cljs
new file mode 100644
index 0000000..603b565
--- /dev/null
+++ b/src/scittle/js_interop.cljs
@@ -0,0 +1,8 @@
+(ns scittle.js-interop
+  (:require
+   [sci.configs.applied-science.js-interop :as j]
+   [scittle.core :as scittle]))
+
+(scittle/register-plugin!
+  ::js-interop
+  j/config)